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Year : 2016  |  Volume : 34  |  Issue : 4  |  Page : 416--420

Exploring the hidden potential of fosfomycin for the fight against severe Gram-negative infections

PV Saiprasad, K Krishnaprasad 
 Department of Medical Services, Glenmark Pharmaceuticals Ltd., Mumbai, Maharashtra, India

Correspondence Address:
P V Saiprasad
Department of Medical Services, Glenmark Pharmaceuticals Ltd., Mumbai, Maharashtra
India

Gram-negative resistance is a serious global crisis putting the world on the cusp of 'pre-antibiotic era'. This serious crisis has been catalysed by the rapid increase in carbapenem-resistant Enterobacteriaceae (CRE). Spurge in colistin usage to combat CRE infections leads to the reports of (colistin and carbapenem resistant enterobacteriaceae) CCRE (resistance to colistin in isolates of CRE) infections further jeopardising our last defence. The antibacterial apocalypse imposed by global resistance crisis requires urgent alternative therapeutic options. Interest in the use of fosfomycin renewed recently for serious systemic infections caused by multidrug-resistant Enterobacteriaceae. This review aimed at analysing the recent evidence on intravenous fosfomycin to explore its hidden potential, especially when fosfomycin disodium is going to be available in India. Although a number of promising evidence are coming up for fosfomycin, there are still areas where more work is required to establish intravenous fosfomycin as the last resort antibacterial for severe Gram-negative infections.

How to cite this article:
Saiprasad P V, Krishnaprasad K. Exploring the hidden potential of fosfomycin for the fight against severe Gram-negative infections.Indian J Med Microbiol 2016;34:416-420

How to cite this URL:
Saiprasad P V, Krishnaprasad K. Exploring the hidden potential of fosfomycin for the fight against severe Gram-negative infections. Indian J Med Microbiol [serial online] 2016 [cited 2017 Feb 23 ];34:416-420
Available from: http://www.ijmm.org/article.asp?issn=0255-0857;year=2016;volume=34;issue=4;spage=416;epage=420;aulast=Saiprasad;type=0