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Year : 2016  |  Volume : 34  |  Issue : 4  |  Page : 506-508

Synergism between fluconazole and methylene blue-photodynamic therapy against fluconazole-resistant Candida strains


1 Department of Natural Sciences, Campus Centro-Oeste D. Lindu, Universidade Federal de São João Del Rei, São João Del Rei, São Paulo, Brazil
2 Department of Animal Science, Instituto de Engenharia Biomédica, Universidade Camilo Castelo Branco, São Paulo, Brazil

Correspondence Address:
J P Lyon
Department of Natural Sciences, Campus Centro-Oeste D. Lindu, Universidade Federal de São João Del Rei, São João Del Rei, São Paulo
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0255-0857.195351

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Photodynamic therapy (PDT) has been proved to be effective against fungi and it may be employed as a coadjutant to conventional antifungal agents, leading to a more effective microbial control minimising side effects. This work evaluates the combined effect of PDT and fluconazole against resistant Candida albicans, Candida glabrata and Candida krusei. The yeasts were submitted to methylene blue-PDT (MB-PDT) in sub-inhibitory concentrations. In the present work, MB-PDT combined with fluconazole was more efficient in the inhibition of the C. albicans and C. glabrata than each treatment alone, being possible to infer that the treatments are synergic.






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2004 - Indian Journal of Medical Microbiology
Published by Wolters Kluwer - Medknow

Online since April 2001, new site since 1st August '04